Eli Lilly and Company

Other

James E Ray

John E Toth

William J Ehlhardt

J Jeffry Howbert

Lowell D Hatfield

Jack W Fisher

Richard C Hoying

Chuan Shih

Sajan Joseph

Philip Parker Waid

Jianping Huang

Rima Salim Al-Awar

Kyle Andrew Hecker

Michael J Martinelli

Vinod Francis Patel

John E Munroe

Bryan Hurst Norman

Guoxin Zhu

Karen Lynn Lobb

Michael Paal

Richard E Moore

Eric D Moher

Gerald B Grindey

Tiechao Li

Venkatraghavan Vasudevan

Cora Sue Grossman

Radhakrishnan Rathnachalam

Rima S Al-Awar

Subbaraju V Gottumukkala

Xun Zhou

A bottle sealing device for reversibly sealing a bottle includes a tube that is hollow. The tube is configured to insert a neck of a bottle such that the tube is reversibly couplable to the bottle with a threaded section of the bottle protruding through an upper end of the tube. A cap is pivotally coupled to the upper end of the tube. The cap also is reversibly couplable to the upper end of the tube. The cap is substantially complementary to the threaded section of the bottle. The cap is configured to reversibly and sealably couple to a lip of the bottle as the cap is reversibly coupled to the tube.

Bottle sealing device

An improved oil and gas drilling control system which utilizes improved braking and feedback technology which, in turn, permits more precise weight-on-bit control and more smooth transitions of weight-on-bit than any existing technology. In addition, the system also permits more accurate feedback and control with respect to drilling depth, pipe transitions, and rate of penetration than prior systems.

Well drilling control system

The present invention provides selective kinase inhibitors of formula (I)

Agents and methods for the treatment of proliferative diseases

The present invention provides selective kinase inhibitors of formula (I).

Cryptophycin compounds

This invention provides certain substituted benzenesulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier.

Antitumor compositions and methods of treatment

This invention provides certain substituted 2,3-dihydrobenzofurylsulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier.

The present invention is directed to azetidinone compounds of the following formula: ##STR1## which are useful as intermediates to carbacephalosporins: ##STR2## These carbacephalosporins are useful as antibacterials.

Chiral intermediates for the preparation of carbacephems

This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.

Intermediates for the preparation of carbacephems

This invention provides certain benzenesulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier, and processes for preparing the benzenesulfonamide derivatives.

This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.

A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.

Methods and compounds for the preparation of carbacephems

This invention provides certain N-phenyl-N'-substituted phenylsulfonylureas compounds, formulations, and a method for treating susceptible neoplasms in mammals using the sulfonylurea compounds.

This invention provides the use of certain indenesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel indenesulfonamide derivatives and their pharmaceutical formulations.

This invention provides certain sulfonimidamide compounds, formulations and method of use of these compounds in treating susceptible neoplasms.

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Indianapolis, IN, United States of America

James E Ray