The University of Texas System

Dow Global Technolgoies LLC

Hoechst Marion Roussel

Aventis Pharmaceuticals Inc.

Aventisub II Inc.

Hoechst Marion Roussel Deutschland Gmbh

James E Hitt

Brian D Scherzer

Keith P Johnston

Robert O Williams, Iii

Christopher John Tucker

Michael K Poindexter

Timothy J Young

Cole A Witham

True L Rogers

Jason T McConville

Jay I Peters

Carol E Mohler

Robert Talbert

David A Hayes

Ian B Gillespie

Paula C Garcia

Nicholas S Beck

Matthew J Hansen

David S Burgess

Mark R Smit

Mark A Nitz

Sandra Stolz-Dunn

Ian A Tomlinson

Christian T Goralski

Edward D Daugs

Alexey L Margolin

Jonathan C Evans

Chi-Hsin Richard King

Paul F Skultety

David H Louks

Hans-Wolfram Flemming

Lian G Rajewski

Thomas T Ortyl

Johannes Nicolaas Koek

Sandra K Stolz-Dunn

Gerard Guillamot

John R Lefler

Sharon K Minish

Sonke Svenson

Frederick M Laskovics

Alan G Bina

Robert A Hawthorne

Marvin J Sack

Thomas He Hilpert

Alonzo L Tigner

The present invention relates to a method of dewatering an aqueous mineral suspension comprising introducing into the suspension a flocculating system comprising a poly(ethylene oxide) copolymer, in particular a copolymer of ethylene oxide and one or more epoxy or glycidyl ether functionalized hydrophobic monomer. Said poly(ethylene oxide) copolymers are useful for the treatment of suspensions of particulate material, especially waste mineral slurries. The invention is particularly suitable for the treatment of tailings and other waste material resulting from mineral processing, in particular, the processing of oil sands tailings.

Treatment of aqueous mineral suspensions with polymeric flocculants

The present invention relates to a method of dewatering an aqueous mineral suspension comprising introducing into the suspension a flocculating system comprising a poly(ethylene oxide) copolymer, in particular a copolymer of ethylene oxide and one or more silane- or siloxane-functionalized glycidyl ether monomer. Said poly(ethylene oxide) copolymers are useful for the treatment of suspensions of particulate material, especially waste mineral slurries. The invention is particularly suitable for the treatment of tailings and other waste material resulting from mineral processing, in particular, the processing of oil sands tailings.

Polymeric flocculants for treating aqueous mineral suspensions

Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (C) of at least about 0.25 &#x3bc;g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Enhanced delivery of drug compositions to treat life threatening infections

The present invention is a method for preparing micron-sized or submicron-sized drug particles comprising contacting a solution comprising a poorly water soluble drug substance and at least one freezable organic solvent with a cold surface so as to freeze the solution; and removing the organic solvent. The resulting particles are also disclosed, as are several embodiments of an apparatus that can be used in performing the method of the present invention.

Drug particles from freezing onto a surface

The present invention relates to a process for preparing a compound of formula (I): ##STR1## wherein R is C.sub.1 -C.sub.10 alkyl, phenyl or substituted phenyl, comprising treating a compound of formula (II): ##STR2## with bis(tributyltin) oxide in an organic solvent selected from the group consisting of o-xylene, m-xylene, p-xylene and mixed xylenes; and subsequently treating the reaction mixture with a compound of formula (III): ##STR3## wherein X is halogen and R is defined as above.

Process for preparing 6-0-monoesters of castanospermine

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Midland, MI, United States of America

James E Hitt