E. R. Squibb Sons, Inc.

James E Heikes

Peter W Sprague

John K Thottathil

Donald S Karanewsky

Edward W Petrillo, Jr

John Anthony Grosso

A method is provided for preparing phosphinic acid compounds, which are useful in preparing certain angiotensin converting enzyme inhibitors, which have the formula ##STR1## wherein R.sub.1 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl;

Method for preparing phosphinic acids used in preparing ace inhibitors

7-Oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided. The final products are used in the treatment of thrombolytic disease.

7-Oxabicycloheptane prostaglandin intermediates

7-Oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided.

7-Oxabicycloheptaine prostaglandin intermediates and method for

Optically active 7-oxabicyclopheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided.

7-Oxabicycloheptane prostaglandin intermediates and method for preparing

Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; R.sub.2 is carboxyl or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.

1,3-Benzodithiolanes

Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; and R.sub.2 is an amino group, a 5- or 6-membered heterocyclic group, a 3-indolyl group, carboxyl, or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.

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East Windsor, NJ, United States of America

James E Heikes