Other

Biogen, Incorporated

Biogen Idec Ma Inc.

James E Dowling

Russell Colyn Petter

Gnanasambandam Kumaravel

Carol L Ensinger

William F Kiesman

He Xi Chang

Ko Chung Lin

Hairuo Peng

Jeffrey Vessels

Gang Yao

Hexi Chang

A pressure equalization device for installation on or at an entry of an attic of a home or other building is described. The pressure equalization device can be an access panel of an attic access hatch. The access panel is a solid, generally flat panel of material such as wood or plastic. The access panel includes an aperture that passes therethrough. The aperture is covered with an air-permeable cover made from a material such as cloth or plastic mesh. The mesh is constructed to allow air to pass through the aperture between the attic and interior of the building for purposes of equalizing pressure between them. Pores of the mesh are sized so that insects, rodents, and other animals and dust and debris cannot pass through and into the interior of the building.

Pressure equalization device for attic

The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula I (See formula on paper copy) 

Triazolopyrazines and methods of making and using the same

The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine Areceptor. Adenosine Aantagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I: 

Adenosine receptor antagonists and methods of making and using the same

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Scituate, MA, United States of America

James E Dowling