3m Innovative Properties Company

Minnesota Mining and Manufacturing Company

Other

Diagen Institute Fur Molekularbrologische Diagnostic, Gmbh

Neogen Food Safety US Holdco Corporation

James E Aysta

William Bedingham

Barry W Robole

Kurt J Halverson

Manjiri T Kshirsagar

Kenneth Brian Wood

Neil Percy

Raj Rajagopal

Metin Colpan

Randall L Knoll

Wilhelm Lewon

Jerald K Rasmussen

Kannan Seshadri

Clinton P Waller, Jr

Richard L Lindstrom

Douglas Eugene Weiss

Joel R Dufresne

Steven P Swanson

Diane North

Evan D Brutinel

Christopher R Kokaisel

Debra L Skelnik

Michael R Harms

Richard M Pieper

David R Gagnon

John T Capecchi

Carl Franzblau

Jesse D Miller

Jeffrey A Lucas

Dewain Robert Goff

Donald F Gibbons

Howard M Leibowitz

Vickery Trinkaus-Randall

Geoffrey Gibson

Rainer A Tuukkanen

Clinton P Waller

The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions.

Sampling devices and methods for concentrating microorganisms

The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.

Live bioload detection using microparticles

A microbial detection article and methods of using the same, the article comprising: a base member comprising a self-supporting water impervious substrate with first and second generally opposed major surfaces; a filter assembly defining a filter assembly aperture therein, and having a composite filter body mounted across the filter assembly aperture; wherein the composite filter body comprises: a microporous membrane, and a water-absorbent layer in fluid communication with the microporous membrane; and a cover sheet.

Microbial detection article having a water-absorbent filter assembly

Live Bioload detection using microparticles

Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group of process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

Sample processing devices

Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface.

Sample processing device compression systems and methods

Sample processing systems for processing sample materials located in sample processing devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate with raised and/or non-planar thermal structures on which the sample processing devices are located during operation of the systems. The systems may also include structure to urge the sample processing devices against the base plate and thermal structures.

Thermal structure for sample processing systems

Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

Systems for using sample processing devices

Growing community of inventors

Stillwater, MN, United States of America

James E Aysta