Massachusetts Institute of Technology

Sonde Health, Inc.

Other

Smiths Detection-edgewood, Inc.

James Douglas Harper

Mark Alexander Hollis

Eric D Schwoebel

Martha Susan Petrovick

Todd H Rider

Trina Rae Vian

Richard Hart Mathews

Bernadette Johnson

Frances E Nargi

Joseph John Lacirignola

Mark Hennessy

Kristine E Hogan

Albert M Young

Shaun R Berry

Raymond S Uttaro

Rose M Joseph

Timothy Stephens

Michael Chen

Linda Marie Mendenhall

Ann Rundell

Darrell Orlyn Ricke

Laura T Bortolin

Allan Heff

Johanna Bobrow

Lalitha Parameswaran

Brian S Helfer

Edward C Wack

James G Watkins

Anna Shcherbina

Joseph Isaacson

Adam M Michaleas

Songeeta Palchaudhuri

Peter T Lansbury

Alan L Davison

John C Schmidt

Eric Scott Clasen

Drew Chapman Brown

Hogyu Han

Philip Fremont-Smith

Weiguo Zhen

Cheon-Gyu Cho

Eric David Schwoebel

Eric Schwoebel

Joseph Lacirignola

Trina Vian

Frances Ellen Nargi

Todd Harrison Rider

Richard H Mathews

Trina R Vian

The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components. The methods of the disclosure do not require any prior knowledge of individual DNA profiles or contributors to the complex DNA mixtures. Moreover, the methods of the disclosure may use any SNP panel, including those panels already existing and those panels specifically designed to maximize performance characteristics of the methods described herein.

Systems and methods for genetic identification and analysis

A system for activating a cued health assessment, which includes an audio receiver for receiving voice samples to measure one of a plurality of voice biomarkers, an audio processing module for extracting one of a plurality of biomarkers from the received voice samples, the audio processing module further classifies the received voice samples to one of plurality of predetermined health states according to the extracted biomarkers, and a voice sample scheduler for activating a cued health assessment module when the classified health state is a clinically actionable health state.

System and method for activation and deactivation of cued health assessment

The present invention provides a system for activating personal assistance services. The system includes an audio data collector adapted to collect a sample of speech, a processing module, and a service activator couple to an output device. The processing module further includes an audio feature extractor that extracts a plurality of acoustic features from the sample of speech, and a classification unit that classifies a status of a user from the plurality of acoustic features. The Service activator activates a personal assistance service according to the status of the user classified by the classification unit.

System and method for activation of voice interactive services based on user state

The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

Optoelectronic detection system

The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.

Pathogen detection biosensor

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

An apparatus for preparing a nucleic acid component of a sample for amplification includes a porous support having an agent that deactivates a nucleic acid amplification inhibitor component of the sample. The apparatus further includes a housing with an opening and defining an interior. The interior of the housing is in fluid communication with the porous support, and at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support. The apparatus also includes a magnetic substrate for separating nucleic acid from a sample.

Apparatus for isolating a nucleic acid from a sample

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Boston, MA, United States of America

James Douglas Harper