University of South Florida

Other

Bausch-lomb Incorporated

James Donald Hayes

Abdul John Malik

Steven K MacLeod

Donald L Herber

Daniel J Stein

A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient ('API') having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent; and (b) adding a compound of the API to said first solution under conditions of high-shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer; wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process.

Method for preparing suspensions of low-solubility materials

A method of preparing a sol-gel monolithic column includes the step of forming a separation bed () from a sol-gel solution in a single process step. This column has improved characteristics for CEC based on its incorporated surface charge and ease of operation due to a lack of or need for end frits. Also, a second type of column includes an optical window () for on-column detection.

Sol-gel monolithic column with optical window and method of making

The present invention provides for a column for use in capillary electrochromatography including a tube, wherein the tube includes an inner surface having a positively or negatively charged, chemically-bonded stationary coating thereon. The present invention further provides for a method of making a column for use in capillary electrochromatography, including a tube, wherein the tube includes an inner surface having a positively or negatively charged chemically-bonded stationary coating thereon, wherein the steps include filling the column with a sol-gel solution, maintaining the sol-gel solution within the column, and forcing the sol-gel solution out of the column with an inert gas. Further, the present invention provides for a method of analytical separation with a column including an inner layer having a positively charged chemically-bonded stationary coating thereon that reverses the direction of electroosmotic flow in the column compared with a column without the positive surface charge. Additionally, the present invention provides for a method of using a column including an inner layer of positively charged chemically-bonded stationary coating thereon by introducing a sample into the column operating under reversed electroosmotic flow due to positively charged chemically-bonded stationary coating.

Sol-gel open tubular ODS columns with charged inner surface for capillary electrochromatography

A simplified lyre holder for flutes is provided which allows full adjustment of both the lyre and support rod therefor, and has specialized securing structure for simultaneously gripping the flute and support rod with manipulation of only a single thumbscrew to greatly facilitate adjustment of the lyre to suit a particular flute player. The holder assembly includes a resilient, unitary, generally C-shaped flute-gripping element having a pair of laterally projecting, bored arms; one of the arms is grooved to adjustably receive the end of the support rod, and a single thumbscrew is positioned within the arm bores such that a simple tightening of the latter serves to lock the assembly in place in a single operation.

Growing community of inventors

Tampa, FL, United States of America

James Donald Hayes