Merck Sharp + Dohme Corp.

Merck + Co., Inc.

James Dellureficio

Ravi P Nargund

Raman Kumar Bakshi

Amjad Ali

Shrenik K Shah

Michael Man-Chu Lo

Shuwen He

Lin Yan

Liangqin Guo

Robert K Baker

Zhixiong Ye

Timothy J Henderson

Brent Whitehead

Edward Metzger

Zhiqiang Guo

Jun Wang

Qingmei Hong

Peter H Dobbelaar

A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy. 

Diazeniumdiolate heterocyclic derivatives

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators

Certain novel N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated piperidine derivatives as melanocortin 4-receptor agonists

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Millington, NJ, United States of America

James Dellureficio