Novartis Ag

James Dale

David Andrew Sandham

Roger John Taylor

Nichola Smith

Thomas Josef Troxler

Kamlesh Jagdis Bala

Duncan Shaw

Robert Alexander Pulz

Mahbub Ahmed

Lisa Ann Rooney

David William Porter

Anne-Marie Edwards

Jessica Louise Taylor

Andrew Brearley

Joe Wrigglesworth

Ian Bruce

Gurdip Bhalay

Jeffrey McKenna

Thomas Anthony Hunt

Darren Mark Legrand

Christopher Thomson

Anne-Marie D'Souza

Ameet Vijay Ambarkhane

Alessandro Mazzacani

Martin Beckett

Ahmed Hamadi

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Carboxamide derivatives

The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.

3-spirocyclic piperidine derivatives as ghrelin receptor agonists

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Organic compounds

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Newmarket, United Kingdom

James Dale