Beckman Coulter, Inc.

3m Innovative Properties Company

James D Mendoza

Hashem Akhavan-Tafti

Renuka De Silva

Wenhua Xie

Michael Salvati

Bruce H Odegaard

Terri McLernon

Nir Shapir

Dean G Binger

Ying Chen

George W Griesgraber

Doris Stoermer

Jason D Bonk

Christopher D Gram

Dean Binger

Terri Mclernon

William C Kieper

Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.

Solution phase homogeneous assays

The present invention provides IRM conjugates that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety in which the covalent link does not depend on UV irradiation.

Immune response modifier conjugates

Growing community of inventors

Robbinsdale, MN, United States of America

James D Mendoza