Wyeth

Other

Pfizer Corporation

James D Clark

Katherine Lin Lee

Lihren Chen

John C McKew

Fuk-Wah Sum

Mark L Behnke

Baihua Hu

Paresh Thakker

Kevin Pong

Steven Y Tam

Valerie Clerin

Suzana Marusic

Wei Li

Steve Yikkai Tam

Richard Vargas

Cara Williams

John C Mckew

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase Aenzymes (cPLA), more particularly including inhibitors of cytosolic phospholipase Aalpha enzymes (cPLA&#x3b1;). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

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This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.

Methods for the use of inhibitors of cytosolic phospholipase A2

This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Methods for treating asthmatic conditions

This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Methods for treating arthritic disorders

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

Process for making an aldehyde

Inhibitors of cytosolic phospholipase A2

N-benzhydryl indole compounds

A housing for the prop of a conventional gasoline or diesel powered marine engine is provided attachable to a bracket mount on the engine. The housing completely encloses the engine's prop and drive shaft and defines a tubular flow path for the water engaged by the prop with the flow path being generally coaxial with respect to the prop's rotation axis. The housing has an anterior inlet port of cross-sectional area A1 and a posterior outlet port of cross-sectional area A2 wherein A1&gt;A2. A smooth transition of the different cross-sectional areas of the tubular housing is effected by an intermediate tapered section. Drive shaft extension means are provided so that the prop rotates in the region of the housing's least cross-sectional area.

Marine prop housing

Growing community of inventors

Acton, MA, United States of America

James D Clark