University of Pittsburgh

Micro Focus Lcc

James Clampffer

Yadong Wang

Eric M Jeffries

Stephen Gregory Walkauskas

Natalya Aksman

Deepak Majeti

Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.

Electrospinning with sacrificial template for patterning fibrous constructs

A complex data type is encoded over columns of a table of a columnar database by mapping fields of the complex data type to the columns. An optimized query can be generated for a query specifying the complex data type. The optimized query specifies the columns to which the fields specified within the query are mapped, instead of specifying the fields. The optimized query can be processed against the database in a late materialization manner to fulfill the query.

Complex data type encoding within columnar database

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Pittsburgh, PA, United States of America

James Clampffer