Beijing University of Technology

Hudson Institute of Medical Research

James Charles Whisstock

Merrill Joy Rowley

Claudia Nold

Ashley Maurice Buckle

Gustavo Fenalti

Marcel Nold

Andrew Ellisdon

Ruby Hong Ping Law

This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric anti-inflammatory polypeptide comprising an amino acid sequence of an IL-37 monomer, the amino acid sequence having a mutation or modification for preventing the anti-inflammatory peptide from forming a homodimer.

IL-37 variants

A crystal comprising an isoform of an N-terminally truncated glutamic acid decarboxylase (GAD) chosen from the group consisting of a monoclinic P2space group with unit cell dimensions of a =84.05&#xb1;2.3 &#x212b;, b=62.74&#xb1;2.3 &#x212b;, c=101.35&#xb1;2.3 &#x212b; and &#x3b2; =106.69&#xb0; (GAD67) or an orthorhombic C222space group with unit cell dimensions of a=78.25&#xb1;2.3 &#x212b;, b=99.05&#xb1;2.3 &#x212b; and c=120.01&#xb1;2.3 &#x212b;(GAD65).

Crystals of human glutamic acid decarboxylase 65 (GAD65)

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Murrumbeena, Australia

James Charles Whisstock