Clemson University

James C Morris

Daniel C Whitehead

Chandima J Narangoda

A drug product and method for treating a parasitic disease in a host is described. The drug product comprises: a carrier matrix; and a drug substance having the formula:  wherein: Ris selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons; each Ris independently selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons; Y represents those elements necessary to form a 5 or 6 membered ring; X is selected from the group consisting of B, O, N, S, Se and P; and n is 1-4 as necessary to complete the valence of X.

Diazacyclobutene derivatives as anti-parasitic drug substances

Provided is a compound having the formula: wherein:Ris selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;Ris selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;each Ris independently selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;X is selected from the group consisting of B, O, N, S, Se and P; andn is 1-4 as necessary to complete the valence of X formed by the reaction of a compound of Formula III: and a compound of Formula IV: 

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Clemson, SC, United States of America

James C Morris