Buckman Laboratories International, Inc.

Roche Diagnostics Gmbh

James C Lee

Stephen D Bryant

Richard A Clark

Pedro A Bonilla

Vanja Margareta King

Xiangdong Zhou

Luis Fernando Del Corral

Mohan D Karve

M Sheldon Ellis

Luis Fernando Corral

The invention provides a solid TCMTB formulation for controlling the growth of at least one microorganism. The use of a solid TCMTB formulation, as compared to a liquid, minimizes user contact and is more readily packaged. A solid TCMTB formulation of the invention contains TCMTB adsorbed onto a water-soluble, salt carrier matrix, with the TCMTB present in an amount effective to control the growth of at least one microorganism, preferably in an aqueous system. Other microbicides and additives may also be incorporated into a solid TCMTB formulation of the invention. In a preferred embodiment, the formulation contains both TCMTB and one or more other microbicides (e.g., methylene bisthiocyanate (MTC)) and a water-soluble, salt carrier matrix. The TCMTB is adsorbed onto the water-soluble salt carrier matrix. The TCMTB and other microbicide are present in a combined antimicrobial amount effective for the control of at least one microorganism. A solid TCMTB formulation may be used in a wide variety of biocide applications. Accordingly, the invention also relates to a method for controlling the growth of at least one microorganism in a liquid, preferably aqueous, system. In particular, the method controls the growth of at least one microorganism in an aqueous system by contacting an aqueous system with a solid TCMTB formulation comprising TCMTB adsorbed onto a water-soluble salt carrier matrix in an amount effective to control the growth of at least one microorganism in the aqueous system.

Solid TCMTB formulations

Novel analogs of phencyclidine (PCP) are disclosed. The analogs are capable of reacting with anti-PCT antibodies and are useful in immunoassays. The following analogs are described: ##STR1## wherein wherein X is --OH or a reporter molecule selected from the group consisting of aminofluorescein and aminomethylfluorescein and n is an integer between 1 and 10, inclusive.

Phencyclidine analogs for immunoassay

A method for stabilizing an enzyme against decomposition at elevated temperatures or by water is described which comprises combining the enzyme with stabilizing amounts of a non-ionic polyether-polyol block-copolymer surfactant. Stabilized compositions based on the enzyme and surfactant are also described.

Enzyme stabilization by oxygen-containing block copolymers

An emulsifier composition containing 1,4-bis(bromoacetoxy)-2-butene (BBAB) is disclosed which has the ability to disperse and/or dissolve uniformly in aqueous systems thereby effectively controlling the growth of microorganisms. The composition contains BBAB and a nonionic emulsifier. A method for inhibiting the growth of microorganisms with this composition in an amount effective to control the growth of microorganisms is also disclosed.

Emulsified compositions of 1,4-bis(bromoacetoxy)-2-butene useful as a

Pesticidal compositions for application to chlorophyl-containing algae or plants containing endothall or a salt thereof and at least one ethoxylated amine of formula I ##STR1## in which R.sub.1 is an alkyl group having 8 to 22 carbon atoms, and is saturated or unsaturated; and the poly(oxyethylene) content (x+y) is greater than 3 but less than or equal to 15. Also disclosed are methods of increasing the effectiveness of endothall or a salt thereof which comprises adding to the endothall or salt thereof an amount of an ethoxylated amine of formula I effective to increase the pesticidal activity of the endothall or salt thereof.

Pesticidal compositions containing ethoxylated fatty amines for

Pesticidal and fertilizer compositions containing at least one compound of formula I

Composition and method for increasing the effectiveness of pesticides

A composition comprising TCMTB and a solid, preferably inert, carrier. The composition is in a powdered form and can be effective for preventing the growth of microorganisms. A method for preparing this composition comprises mixing the TCMTB with the carrier.

Growing community of inventors

Memphis, TN, United States of America

James C Lee