The University of Texas System

Dispersol Technologies, LLC

Millennium Pharmaceuticals Limited

Integrico Composites, Inc.

Austinpx, LLC

James C DiNunzio

Robert O Williams, Iii

Dave A Miller

Chris Brough

James William McGinity

Qunli Xu

Katherine M Galvin

Rachael L Brake

Viviana Bozon

Ching-Kuo J Chow

Karuppiah Kannan

James W Mcginity

Yuki Kodono

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Thermo-kinetic mixing for pharmaceutical applications

The invention relates to a pharmaceutical composition comprising Compound 1 or a pharmaceutically acceptable salt thereof for the treatment of cancer and a process for its preparation. The invention also relates to administering the pharmaceutical composition to a patient according to an intermittent dosing regimen.

Pharmaceutical formulations of a pan-RAF kinase inhibitor and processes for their preparation

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Bridgewater, NJ, United States of America

James C DiNunzio