Eisai R&d Management Co., Ltd.

Other

James Bradford Kline

Luigi Grasso

Jared Spidel

Kenzo Muramoto

Toshio Imai

Yoshimasa Sakamoto

Miyuki Nishimura

Earl Albone

Tatsuo Horizoe

Tetsu Kawano

Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 ('Cys80') in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

Cys80 conjugated immunoglobulins

CYS80 conjugated immunoglobulins

The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Neutralizing anti-CCL20 antibodies

Nucleic acids encoding neutralizing anti-CCL20 antibodies

A fluid dispenser bottle of the upright variety having a pump dispenser (spout or spray nozzle) at the upper end thereof wherein provided in the interior base of such bottle to direct the contents into a sump at such base, a draw tube engaging within and extending upwardly from the sump to the pump dispenser, and slots in the draw tube to permit the contents of the bottle to flow into the sump.

Dispenser bottle with internal pump

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Morgantown, PA, United States of America

James Bradford Kline