Auburn University

James Barbaree

Vitaly J Vodyanoy

Bryan A Chin

William Charles Neely

Suram T Pathirana

Timothy D Braden

Zhongyang Cheng

Alexandre M Samoylov

Valery A Petrenko

Howard C Wikle

Tung-Shi Huang

Iryna Sorokulova

Valery A Pentrenko

Viswaprakash Nanduri

W Charles Neely

A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target ligand binds thereto. A driver is also provided to emit a varying magnetic field such that the MSP produces a resonance response detectable by a measurement device configured to receive and detect changes in the resonance response that are due to alterations of the binding element. The MLSD and assays find use in identifying and quantitating ligands as well as chemicals and environmental conditions in a sample or patient.

Magnetostrictive ligand sensor

Compositions and methods for the reversible preservation of biological samples are provided. The compositions include natural polymers such as pullulan or acacia gum, including derivations and modifications thereof, which are usefull as a reversible preservation solution. A method is provided for using pullulan or Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.

Use of pullulan to isolate and preserve biological material

Compositions and methods for the reversible preservation of biological samples are provided. The compositions includeGum, including derivations and modifications thereof which are useful as a reversible preservation solution. A method is provided for usingGum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.

Use of acacia gum to isolate and preserve a biological receptor on a biosensor

Methods and compositions for identifying and characterizing one or more ligands of a peptide are provided. In particular, the invention provides a phage ligand sensor device (PLSD) comprising a sensor coupled to a binding element of interest. Binding elements of interest comprise phage displaying at least one foreign peptide. The PLSD and assays find particular use in identifying and characterizing ligand-peptide interactions.

Phage ligand sensor devices and uses thereof

Use of Acacia Gum to isolate and preserve biological material

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Dadeville, AL, United States of America

James Barbaree