Rutgers, the State University of New Jersey

Provid Pharmaceuticals Inc.

James Bacci

Richard H Ebright

Gary Olson

Christopher Self

Yon W Ebright

Juan Shen

Anne-Cecile Hiebel

William Solvibile

The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Antibacterial agents: aryl myxopyronin derivatives

The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

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Monmouth Junction, NJ, United States of America

James Bacci