Merck + Co., Inc.

Other

Merial Limited

James B Williams

Lowell R Macy

Raymond E Hopponen

Howard E Bode, Sr

Pak-Kan A Lo

Roger A Wilson

Russell U Nesbitt

Rey T Chern

Hoo-Kyun Choi

Thomas James Schnabel

Kaushik J Dave

A masonry unit may include a main portion having end surfaces, a primary side surface, and a secondary side surface, and an auxiliary portion positioned adjacent to the main portion and defining an auxiliary void. The auxiliary portion may be connected to the main portion at the secondary side surface. The auxiliary portion may include an auxiliary wall being spaced from the secondary side surface to define the auxiliary void therebetween, and at least one bridging web extending across the auxiliary void and connecting the auxiliary wall to the main portion, the at least one bridging web being inset from the opposite ends of the unit, the at least one bridging web being integrally formed with the main portion and the auxiliary wall. The auxiliary void may extend from one end to another end of the unit and may extend from the top to the bottom of the unit.

Masonry block for in situ insulation application

Water miscible pharmaceutical compositions containing up about 40% of a marcrolide such as an azalide antibiotic are prepared by reaction of the macrolide with acid in a non-aqueous water miscible organic solvent system.

Water miscible macrolide solutions

Long-acting injectable formulations are formed from a) a therapeutic agent selected from insecticides, acaricides, parasiticides, growth enhancers or oil-soluble NSAIDs, b) hydrogenated castor oil, and c) a hydrophobic carrier comprising i) triacetin, benzyl benzoate, ethyl oleate, or a combination thereof, and ii) acylated monoglycerides, propyl dicaprylates/dicaprates, caprylic/capric acid triglycerides or a combination thereof.

Long acting injectable formulations containing hydrogenated caster oil

Water miscible pharmaceutical compositions containing up to about 40% of a macrolide antibiotic are prepared by reaction of the macrolide with acid in a non-aqueous water miscible organic solvent system.

The present invention is concerned with an oral pharmaceutical formulation containing a proton pump inhibitor (PPI) which is suitable for the treatment of gastric acid related diseases in man and animals. More specifically, the composition is a paste, and is particularly suitable for delivery of a proton pump inhibitor to horses.

Stable, ready-to-use pharmaceutical paste composition containing proton

There is disclosed a topical multiple-point-application formulation containing a solution of a polymeric material and an avermectin compound (active ingredient) which has been discovered to provide superior efficacy against ectoparasites, such as fleas and ticks and endoparasites such as nematodes and heartworms, when compared to conventional formulations. The formulation contains the avermectin active ingredient and up to 50% of the polymeric material.

Pour-on formulations containing polymeric material

Ivermectin, an antiparasitic agent which is insoluble and unstable in water, is formulated in glycerol formal and propylene glycol. These liquid formulations are suitable for parenteral administration for the treatment of parasitic infections and demonstrate improved efficacy and a broadened spectrum over previous formulations.

Non-aqueous ivermectin formulation with improved antiparasitic activity

Ivermectin, an antiparasitic agent which is insoluble and unstable in water, is solubilized by the formation of colloidal particles, called micelles, with surface active agents as solubilizers and stabilized by using cosolvents and/or appropriate substrates in the aqueous formulation. The liquid formulations are suitable for use as parenteral or oral administration for the treatment of parasitic infections.

Solubilization of ivermectin in water

A rug or mat cleaning apparatus is disclosed which is comprised of first a dry lint and dust removing section, then a water or like liquid containing vessel having an initial wash section and then a rinse section and then finally a wringer section. A mat to be cleaned is passed through a first conveying roller at a slower driving speed. Thereafter, the mat or rug enters an increased speed brush which both removes dirt and agitates the surface of the rug and beats it to knock loose undesireable dirt and like particles. In the wash section of the apparatus, alternating feed rollers and brush rollers carry the mat or rug to be cleaned. Each feed roller clamps and holds the rug to prevent slipping while conveying it at a slower linear speed. Each brush roller provides a brushing surface having a substantially higher linear speed than the surface of the conveying rolls. Thus, a 'tuck' or crease is created in the rug between each high speed roller brush and its adjacent and following slower conveying roll. A wringer is provided at the end of the apparatus to remove extraneous water from the rug after its cleansing. Pressure belts are provided above the cleaning brushes for enhanced cleaning and operation. A special beater roller with projecting ridges is also included.

Mat or rug cleaning system

A rug or mat cleaning system is disclosed which is comprised of first a dry lint and dust removing section, then a water or like liquid containing vessel having an initial wash section and then a rinse section and then finally a wringer section. A mat to be cleaned is passed through a first conveying roller at a slower driving speed. Thereafter, the mat or rug enters an increased speed brush which both removes dirt and agitates the surface of the rug and beats it to knock loose undesireable dirt and like particles. In the wash section of the system, alternating feed rollers and brush rollers carry the mat or rug to be cleaned. Each feed roller clamps and holds the rug to prevent slipping while conveying it at a slower linear speed. Each brush roller provides a brushing surface having a substantially higher linear speed than the surface of the conveying rolls. Thus, a 'tuck' or crease is created in the rug between each high speed roller brush and its adjacent and following slower conveying roll. A wringer is provided at the end of the system to remove extraneous water from the rug after its cleansing. Pressure belts are provided above the cleaning brushes for enhanced cleaning and operation. A special beater roller with projecting ridges is also included.

Mat or rug cleaning process using roller brush

A soluble complex of an insoluble drug, exemplified by Rafoxanide is formed with polyvinylpyrrolidone and water. The complex is formed by combining the insoluble drug and polyvinylpyrrolidone in a suitable water miscible organic solvent, preferably acetone or glycerolformal, and water. The complex is formed in situ. The solvent may be removed, if desired, and the complex remains in aqueous solution. The aqueous solution is then suitable for injection and may be used to treat fasciola or liver fluke infections.

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Lansdale, PA, United States of America

James B Williams