The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America As Represented by the Department of Health

The Penn State Research Foundation

Louisiana State University and Agricultural & Mechanical College

Wake Forest University

H. Lee Moffitt Cancer Center and Research Institute, Inc.

The United States of America As Represented by the Dept. of Health &

James B Mitchell

Murali Krishna Cherukuri

Sankaran Subramanian

Angelo Russo

David A Wink

Rolf G Tschudin

Murali K Cherukuri

Murali C Krishna

Nallathamby Devasahayam

Ramachandran Murugesan

James E Liebmann

Frank J Gonzalez

Thomas J Pohida

Mark S Mirotznik

Bradley Allen Roth

Fei Li

Andrew D Patterson

Stephen Hahn

Paul G Zablocky

John Bourg

John A Cook

Shingo Matsumoto

Changtao Jiang

Janusz Koscielniak

Cen Xie

Paul D Smith

Robert J Gillies

Walter S Friauf

Shantu G Amin

Dhimant H Desai

S Bruce King

W Marston Linehan

Frank S Harrington

Vyomesh Patel

Alfredo Molinolo

J Silvio Gutkind

Anne Marie DeLuca

Amran Samuni

Ana P Cotrim

William G Degraff

Mobae Afeworki

Wilmarie Flores-Santana

John U Dennis

William DeGraff

Amram Samuni

Tracey A Rouault

Daniel Neil Granger

Shantu Amin

Matthew B Grisham

Ingeborg Hanbauer

Kazutoshi Yamamoto

Keita Saito

Dhimant Desai

Jeffrey R Brender

Shun Kishimoto

Jeeva P Munasinghe

Hellmut Merkle

Ghadi Salem

Ramiro Iglesias-Bartolome

Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model.

Denoising of dynamic resonance spectroscopic imaging using low rank approximations in the kinetic domain

The System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) was developed to quantify activity levels and behavior patterns for mice housed within a home cage that, optional, may be disposed in a commercial ventilated cage rack. The SCORHE home-cage in-rack design provides daytime and night-time monitoring with the stability and consistency of the home-cage environment. The dual-video camera custom hardware design makes efficient use of space, does not require home-cage modification, and is animal facility user-friendly. In various embodiments, a software application integrates the two video streams to extract several mouse activity measures.

Systems and methods of video monitoring for vivarium cages

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R, R, R, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal. 

Inhibitors of the farnesoid x receptor and uses in medicine

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R, R, R, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least Cone compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal. 

Inhibitors of the farnesoid X receptor and uses in medicine

The identification of pOlowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a hypoxia-sensitive agent in a subject, by administering to the subject a therapeutically effective amount of the hypoxia-sensitive agent and a therapeutically effective amount of a pOlowering agent. Methods of treating a subject with a tumor, by administering to the subject a therapeutically effective amount of a pOlowering agent and a therapeutically effective amount of a hypoxia-sensitive agent are also disclosed.

Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors

Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof.

Methods of preventing the development of mucositis and related disorders

Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof:  in which R, R, R, R, R, R, R, R, R, R, R, and n are defined herein and pharmaceutical compositions thereof. Further disclosed is a method of treating or preventing various disorders, such as inflammation, cancer, diabetes, a cardiovascular disorder, weight gain, polyps, and/or chronic pain, in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt or enantiomer of formula (I). A method of imaging the compound or pharmaceutically acceptable salt or enantiomer of formula (I) in the body of the animal is also provided.

Nitroxide modified non-steroidal anti-inflammatory compounds and uses thereof in the treatment and prevention of diseases or disorders

The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2&#x3b1;.

Nitroxide therapy for the treatment of von Hippel&#x2014;Lindau disease (VHL) and renal clear cell carcinoma (RCC)

An echo-based single point imaging (ESPI) system () providing high-resolution oxygen images of a sample is disclosed. The ESPI system () employs spin echo detection of the resonance from a spin probe and concurrent Single Point Imaging (SPI) for spatial encoding of the oxygen concentration within the sample. Images are derived by comparing spin echo intensities of two images reconstructed at two time points selected at identical time intervals on either side of a refocusing pulse, eliminating artifacts associated with sample magnetic susceptibility and field inhomogeneity effects.

Quantitative oxygen imaging systems and methods using echo-based single point imaging

An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for processing the signal data, using means including a digital signal processor.

Fast electron paramagnetic resonance imaging (EPRI) using CW EPR spectrometer with sinusoidal rapid-scan and digital signal processing

An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for transmitting, receiving and processing the signal data, using means including a digital signal processor.

Fast electron paramagnetic resonance imaging (EPRI) in the CW EPR mode using rapid-scan in the presence of rotating gradients and direct detection with transmit/receive and data processing in a digital signal processing platform

The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula (I) or Formula (II): in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method 

Use of tempol for the treatment of Li-Fraumeni syndrome and ataxia telangiectasia

Nitroxides as protectors against oxidatives stress

A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.

Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy

A system for performing pulsed RF FT EPR spectroscopy and imaging includes an ultra-fast excitation subsystem and an ultra-fast data acquisition subsystem. Additionally, method for measuring and imaging in vivo oxygen and free radicals or for performing RF FT EPR spectroscopy utilizes short RF excitations pulses and ultra-fast sampling, digitizing, and summing steps.

In vivo imaging and oxymetry by pulsed radiofrequency paramagnetic

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Damascus, MD, United States of America

James B Mitchell