Monsanto Technology LLC

Ecogen, Inc.

Monsanto Company

Other

Certis Usa, LLC

James Arthur Baum

Stanislaw Flasinski

James Kevin Roberts

Sara Ann Salvador

Artem G Evdokimov

Arlene R Howe

Xiaoran Fu

Thomas Cerruti

Farhad Moshiri

Amy Jelen Gilmer

Jay Paul Morgenstern

Leigh H English

Victor M Guzov

Crystal L Dart

William P Donovan

Anne-Marie Light Mettus

Bei Zhang

Jinling Hung Wang

Larry A Gilbertson

Wei Wu

Gregory R Heck

David K Kovalic

Maolong Lu

Andrew M Wollacott

Mark J Rupar

Timothy J Rydel

Tichafa R I Munyikwa

Moritz Von Rechenberg

Meiying Zheng

Eric J Sturman

Chih-Rei Chu

Halong Vu

Thomas M Malvar

Ty T Vaughn

Haitao Zhang

Lisa Marie Weaver

Allen T Christian

Catherine Alice Chay

Yuping Tan

Annette C Slaney

Geert Plaetinck

Thomas J LaRosa

Claire A CaJacob

Wendy T Maddelein

Elizabeth Pease

Thomas J Larosa

David Joseph Bowen

Uma R Kesanapalli

Pascale Feldmann

Xiaohong Shi

Uma Rao Sukuru

Stephen R Penn

Irene Maria Antonia Nooren

Jason S Milligan

Robert M McCarroll

Deborah G Rucker

William P Clinton

David J Chi

Moritz W F Von Rechenberg

Brian M Turczyk

Collin M Stultz

Carlos E Soto

Temple F Smith

Kevin A Jarrell

Tichafa R Munyikwa

Christina Marie Taylor

John W Pitkin

Heather M Anderson

Brian Donovan Eads

Judith C Donovan

Lex Evan Flagel

Irene Nooren

Jeffrey R Nageotte

Karina Krasomil-Osterfeld

Brian Edward Weiner

James T Engleman

Brian B Hauge

Agoston Jerga

Ann-Marie Light Mettus

Pascale Feldman

Gerrit Cornelis Segers

Jeremy A Kroemer

Tichafa Ri Munyikwa

Artem Evdokimov

Thomas A Cerruti

Pesticidal proteins (FFPP's) are used to produce derivatives (DP's) that are ineffective and disabled relative to conferring toxic properties upon a target pest, yet the ability of the DP to bind to the receptor to which said FFPP binds is unaffected. Such DP's are useful in inhibiting the FFPP from which it was derived when both are fed to a target pest and for comparing receptor binding capability and efficiency relative to different FFPP's from which the DP has been derived, providing for an assessment of different FFPP's relative to each other, and providing uniformity and certainty in combinations of such FFPP's for compositions, including transgenic plants, that can be used to control pest populations susceptible to both FFPP's, creating more durable transgenic plant products, inhibiting the development of resistance to such FFPP's when used in plants commercially, and in providing a durable and viable resistance management strategy for crops using such FFPP combinations. Polynucleotide sequences intended for use in expression of the DP's and FFPP's are also provided. Particular embodiments provide methods of designing and preparing DP's, as well as compositions and methods of using DP's and the FFPP's from which the DP's have been derived in more effective pesticidal compositions and products.

Methods and compositions for making and using compatible insecticidal proteins

Engineered Cry1Da amino acid sequences are provided that exhibit improved Lepidopteran insecticidal activity and an enhanced Lepidopteran spectrum compared to the naturally occurring Cry1Da protein toxin. Polynucleotide sequences intended for use in expression of the improved proteins in plants are also provided. Particular embodiments provide compositions containing insect inhibitory amounts of the engineered proteins, as well as recombinant plants, plant parts, and seeds containing polynucleotide constructs encoding one or more of the improved engineered proteins.

Lepidopteran-active Cry1Da1 amino acid sequence variant proteins

The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

Proteins toxic to Hemipteran insect species

Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.

Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests

Disclosed herein are nucleotide sequences encoding an insecticidal protein exhibiting Lepidopteran inhibitory activity, as well as novel insecticidal proteins referred to herein as a BCW 001, BCW 002, BCW 003, and BCW toxic protein-containing chimeras and BCW toxin insecticide, transgenic plants expressing the chimeras or the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.

Pesticidal toxin proteins active againstinsects

The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.

Compositions and methods for control of insect infestations in plants

Proteins toxic to hemipteran insect species

The present invent in disclosesinsect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.

Methods for genetic control of insect infestations in plants and compositions thereof

Disclosed herein are nucleotide sequences encoding an insecticidal protein exhibitinginhibitory activity, as well as novel insecticidal proteins referred to herein as a BCW 001, BCW 002, BCW 003, and BCW toxic protein-containing chimeras and BCW toxin insecticide, transgenic plants expressing the chimeras or the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.

Pesticidal toxin proteins active against lepidopteran insects

Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.

Compositions and methods for the improved production and delivery of RNA by efficient transcription termination

Growing community of inventors

Webster Groves, MO, United States of America

James Arthur Baum