Eli Lilly and Company

James Andrew Jamison

Michael J Rodriguez

William W Turner

Venkatraghavan Vasudevan

Stephen A Hitchcock

William Wilson Turner, Jr

Peter S Borromeo

Donmienne Doen Mun Leung

Jennifer Rebecca Allen

Bin Liu

Mark J Zweifel

Jacqueline Mary Wurst

Venkatraghaven Vasudevan

Lisa M LaGrandeur

Stephen Andrew Hitchcock

William Wilson Turner

Provided herein are compounds that are glucocorticoid receptor agonists useful for the treatment of autoimmune and inflammatory diseases, processes for preparing these compounds, and pharmaceutical compositions comprising these compounds.

Glucocorticoid receptor agonists

The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.

Muscarinic agonists

Cyclic peptide antifungal agents

The present invention relates to compounds of formula

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: ##STR1## wherein R', R', R.sup.x1, R.sup.x2, R.sup.y1 -R.sup.y4, R.sup.z1, R.sup.z2, a, b, c, d, e, R.sup.0, R.sup.1 and R.sup.2 are defined as in the specification.

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: ##STR1## wherein: R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;

Cyclic peptide antifungal Agents

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I ##STR1## wherein: R', R', R'', R.sup.x1, R.sup.x2, R.sup.y1, R.sup.y2, R.sup.y3, R.sup.y4 and R.sup.0 are as defined hereinabove; and R.sup.2 is ##STR2## R.sup.3 is ##STR3## R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are independently hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.12 alkynyl, C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.12 alkylthio, halo, or --O--(CH.sub.2).sub.m --[O--(CH.sub.2).sub.n ].sub.p --O--(C.sub.1 -C.sub.12 alkyl) or --O--(CH.sub.2).sub.q --X--R.sup.4 ; m is 2, 3 or 4; n is 2, 3 or 4; p is 0 or 1; q is 2, 3 or 4; X is pyrrolidino, piperidino or piperazino; and R.sup.4 is hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.12 cycloalkyl, benzyl or C.sub.3 -C.sub.12 cycloalkylmethyl; or a pharmaceutically acceptable salt thereof.

Growing community of inventors

Indianapolis, IN, United States of America

James Andrew Jamison