Elizabeth Arden, Inc.

Btg International Limited

Onyx Pharmaceuticals, Inc.

Elizabeth Arden International, Sarl

James Alan Kerschen

Andrew S Thompson

Joseph Abernathy Lewis, Ii

Joseph C DiNardo

Eberhard Wieland

Falko Diedrich

Birgit Neudecker

Peter C Wade

Alexander James Bridges

Sean Dalziel

James Robert Zeller

Olivier Dapremont

Thomas Elliott Jacks

Milind D Choubal

Hyunjung Kim

Sean Mark Dalziel

Joseph A Ii Lewis

A new method for the synthesis of L-Glutamyl-&#x3b3;-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.

Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta (G) quinazoline trisodium salt

The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.

Compositions containing carboxylic acid-substituted derivatives

A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N&#x2014;{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-&#x3b3;-glutamyl}-D-glutamic acid (ONX-0801). 

Synthesis of cyclopentaquinazolines

The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.

Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof

Skin treatments with carboxylic acid-substituted idebenone derivatives

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Somerset, NJ, United States of America

James Alan Kerschen