The General Hospital Corporation

Other

James Adam Hendricks

Ralph Mazitschek

Stephen J Haggarty

Balaram Ghosh

Surya Reis

Alexandra M Courtis

Stephen John Haggarty

This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.

Photoswitchable HDAC inhibitors

Embodiments of the present invention provide a safety support apparatus for a cabin over engine (COE) truck cabin elevated in a raised position. The safety support apparatus provides a base member having a clamp mechanism which adjusts to truck chassis designs with rails of varying thicknesses. The frame of the safety support apparatus provides a receiver which may engage the bottom of an elevated truck cabin. The frame and base member are adjustable to allow configuration on either side of a truck cabin and deployment of the support apparatus at a range of angles.

Safety support apparatus

This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.

BODIPY dyes for biological imaging

This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: (a) is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent. 

Bodipy dyes for biological imaging

This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.

A carpet installation device is provided which enables a carpet installer to spread and tuck a carpet while the installer is in a substantially upright position. The device comprises a blade having a generally flat bottom edge, an elongate shaft extending upwardly from the blade, a hand grip on the shaft, and an arm bracket on the shaft above the hand grip. The shaft includes a lower portion, an upper portion horizontally offset from the lower portion, and a transition portion extending between the lower portion and the upper portion. The transition section is sized such that when the installer grasps the hand grip, his arm will be substantially aligned with the shaft bottom portion when his arm is generally in contact with the shaft upper portion. Preferably, the shaft top portion is offset from the shaft lower portion by approximately the width of a user's hand.

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Watertown, MA, United States of America

James Adam Hendricks