The United States of America as Represented by the Secretary of

Monsanto Company

James A Webster

James A Ellard

Marvin L Oftedahl

David L Cobb

Brian L Doyle

David H Smith, Jr

Howard M Solomon

An improvement in the production of methotrexate as set out in Ellard U.S. Pat. No. 4,080,325. It has been found that magnesium oxide facilitates the coupling reaction by acting as an acid acceptor. The dense grade of magnesium oxide is preferred in molar proportions of 2 to 4 moles of magnesium oxide per mole of 2,4-diamino-6-hydroxymethylpteridine. Further, the triphenylphosphine oxide which is generated by hydrolysis of the protecting groups is removed from the reaction stream by utilization of toluene or BTX-type solvents.

Separation of triphenylphosphine oxide from methotrexate ester and

An improved pharmaceutically active derivative of a copolymer of olefin monomer and .alpha.,.beta.-unsaturated polycarboxylic anhydride is prepared by reacting the copolymer with aqueous ammonia, spray drying the resulting aqueous solution of half-amide, half-ammonium salt and thermally imidating the resulting substantially dry, solid particulate product by simultaneous treatment with elevated temperature and removal of water until 5-40% of the derivative half-amide, half-ammonium salt groups are converted to imide groups.

Polymeric anti-tumor agent and method of preparation

A rotating row marker equipped with both transverse and longitudinal imprinting projections impresses a grid-type pattern into the soil for precise placement of seeds or seedlings in a subsequent planting operation. One of the transverse projections houses an eccentric weight for gravitationally returning the row marker to a predetermined position when the row marker is raised above the earth.

Rotating field plot row marker

Growing community of inventors

Dayton, OH, United States of America

James A Webster