The United States of America As Represented by the Department of Health

Shunichi Yamaguchi

Michael A. Rogawski

Mariena V. Mattson

James A. Monn

Kenneth C. Rice

Arthur E. Jacobson

Andrew Thurkauf

James A Monn

Kenner C Rice

Andrew Y Thurkauf

Anita H Lewin

Arthur E Jacobson

Michael A Rogawski

Phil Skolnick

Mariena V Mattson

Juan-Carlos Marvizon

Kenneth C Rice

A method is disclosed for the treatment of neuropsychopharmacological disorders which are associated with or result from excessive activation of the N-methyl-D-aspartate receptor complex, which method comprises administering an effective neuropsychopharmacological disorder-treating amount of a compound possessing partial agonist properties for the strychnine insensitive glycine modulatory sites of N-methyl-D-aspartate receptors. Exemplary of partial agonists which are useful in the method of the invention are 1-aminocyclopropanecarboxylic acid, and associated derivates thereof. Novel injectable pharmaceutical compositions are also disclosed.

Partial agonists of the strychnine insensitive glycine modulatory site

This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for treatment of patients with generalized epilepsy or partial (symptomatic) epilepsy using compounds of the formula: ##STR1## This invention also relates to compounds, compositions and methods of treatment for drug craving in patients addicted to cocaine.

5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of

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Gaithersburg, MD, United States of America

James A Monn