University of Pennsylvania

Other

James A Hoxie

Robert Doms

Trevor L Hoffman

Michael Endres

Joseph B Rucker

Paul Bates

John Balliet

Dennis L Kolson

Celia C LaBranche

Lawrence Brass

George Lin

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

Method for the production of antibodies that bind to multiple membrane spanning proteins

Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins

Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins

The present invention relates to replication competent variants of mammalian immunodeficiency virus comprising mutations and/or deletions of the V3 hypervariable loop and compensatory mutations, as well as methods for producing such variants. The invention also relates to V3-loop deletion mammalian immunodeficiency virus mutants that have compensatory mutations, deletions of the V1/V2 loops, or both. The invention further relates to isolated Env, gp120 polypeptides, and gp41 polypeptides comprising novel mutations useful in conjunction with, or separate from, a virus of the invention, as well as nucleic acids encoding the same.

Compositions, method and kits relating to deletion mutations of immunodeficiency virus gp120 hypervariable regions

The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.

CD4-independent HIV envelope proteins as vaccines and therapeutics

The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same.

Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same

Antibodies directed against cellular coreceptors for human

Method for detecting thrombin-induced cell activation via a system of detection capable of determining the presence of the cleaved peptide fragment of the thrombin receptor are provided. These methods are used in diagnosing and treating a pre-thrombotic state or thrombotic disorder in a patient. Detection kits to be used with this method are also provided.

Method and kit for detection of thrombin receptor activation of

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Berwyn, PA, United States of America

James A Hoxie