Eupraxia Pharmaceuticals Inc.

Eupraxia Pharmaceuticals USA LLC

Guidestar Medical Devices

Accuro Technologies Inc.

James A Helliwell

Amanda Malone

Thomas H Smith

Marc Michael Baum

Rafi Chapanian

Richard Liggins

Michael Dolphin

Simon F Cooke

Amanda M Malone

Brianna B Carrels

Michael D Dolphin

Michael Wilmink

Described herein are sustained release formulations of polymer-coated local anesthetic agents, and methods for using the same to relieve or manage pain, including postsurgical pain.

Sustained release of formulations of local anesthetics

Provided is an epidural device configured to inhibit or substantially or completely prevent further progression of an epidural needle upon entry of the needle into the epidural space. When the needle is inserted into the ligamentum of the patient's back, the device may be pressurized with fluid using the resistance of the dense ligament to maintain pressure. This pressurization may lock a pushing mechanism in place relative to the needle such that the pushing mechanism can be used to advance the needle. Once the epidural space is reached, the fluid (e.g., saline or air) enters the epidural space, and the release of pressure may cause the trigger mechanism to disengage from the sliding pusher, allowing the pusher to slide along the body of the construct. The device thus may provide the ability to detect the epidural space using pressure loss while preventing the needle from advancing into the dura once the space is reached. In a preferred aspect, the device may prevent premature triggering when there is a slow flow of fluid from the epidural needle into the surrounding tissue.

Epidural device for detection of and needle placement in epidural space

Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith

Growing community of inventors

Victoria, Canada

James A Helliwell