Russian-american Institute for New Drug Development

Other

University of Minnesota

James A Halikas

Tatiana A Voronina

Arkady M Likhosherstov

Vitaly P Peresada

Sergei Borisovich Seredenin

Rita U Ostrovskaya

Taisija L Garibova

Sergey B Seredenin

Alexander P Skoldinov

Tatiana A Gudasheva

Gennady M Molodavkin

Grigori G Rozantsev

Sergei S Trophimov

A novel class of substances of N-acyl-prolyldipeptides, which possess psychotropic activity and particularly facilitate learning and memory are described. The N-acyl-prolyldipeptides of the invention have the formula: ##STR1## wherein R.sup.1 =(C.sub.4 -C.sub.5) alkyl, cycloalkyl, aralkyl, or aryl; R.sup.2 =H.sub.1 (C.sub.1 -C.sub.4) alkyl, carbamidoalkyl, or carbalkoxyalkyl; R.sup.3 =NH.sub.2, NH(alkyl), N(alkyl).sub.2, OH, or alkoxy; and n=0-3, preferably 0-2.

Biologically active n-acylprolydipeptides having antiamnestic,

1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives having the formula (Formula I) ##STR1## and therapeutically acceptable acid addition salts thereof (Formula I.HX), wherein: R.sup.1 =hydrogen or acyl groups; and R.sup.2 =hydrogen or substituted aminomethyl groups. Said compounds and their acid addition salts have psychotropic activity, particularly anxiolytic activity.

1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

The craving for cocaine and use of cocaine among users may be reduced by administration of valproic acid. Cocaine-usage is effectively treated with valproic acid administration.

Treatment for cocaine use employing valproic acid

The craving for cocaine and use of cocaine among users may be reduced by administration of carbamazepine. Cocaine-usage is effectively treated with the carbamazepine administration.

Treatment for cocaine use

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North Oaks, MN, United States of America

James A Halikas