Smithkline Beecham Corporation

Other

Human Genome Sciences, Inc.

Beth Israel Deaconess Medical Center, Inc.

Smithkline Beckman Corporation

James A Fornwald

Martin M Rosenberg

James E Strickler

Francis J Schmidt

Mary E Brawner

Dean P Taylor

Thomas R Berka

Joselina G Gorniak

Gregg A Hastings

Craig W Adams

Zdenka Ludmila Jonak

Stephen H Trulli

Jonathan Alexander Terrett

The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.

METH1 polynucleotides

This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.

Protein protease inhibitors from streptomyces

A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter; P2 promoter; P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.

Gal operon of streptomyces

This invention relates to novel protein protease inhibitors as well as DNAs encoding same and vectors and transformed host cells useful for the recombinant production of the inhibitors.

A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter, P2 promoter, P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.

Growing community of inventors

Norristown, PA, United States of America

James A Fornwald