Eli Lilly and Company

Purdue Research Foundation

James A Clemens

Jill A Panetta

Michael E Flaugh

Michael J Sofia

Diane T Stephenson

Henry U Bryant

Nicholas J Bach

Edmund C Kornfeld

Larry J Black

John M Cassady

This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of phospholipase A.sub.2. This invention also provides a series of compounds which are useful as inhibitors of phospholipases A.sub.2, especially cytosolic phospholipase A.sub.2.

Phospholipase A.sub.2 inhibitors

Use of PLA.sub.2 inhibitors as treatment for alzheimer's disease

Provided are methods of treating inflammation, arthritis and muscular dystrophy and preventing ischemia-induced cell damage employing certain phenol and benzamide compounds.

Method for treating inflammation, ischemia-induced cell damage and

A method for improving primary memory or learning in a mammal comprising administering a 5-hydroxytryptamine receptor agonist which is selective for the 5-hydroxytryptamine-1A receptor subtype, or a pharmaceutically acceptable salt thereof.

Method for improving primary memory and/or learning

Method for treating inflammation

Derivatives of melatonin and the pharmaceutically acceptable salts thereof are useful for therapeutically treating hormonally dependent mammalian breast carcinoma. Combination treatments of melatonin derivatives and an antiestrogen compound are especially useful.

Melatonin derivatives and combinations with antiestrogen compounds for

A method of inhibiting bone demineralization comprising administration of an effective amount of a compound having the formula ##STR1## where X is CH or N;

Method of inhibiting demineralization of bone

Mammary cancers are inhibited by administration of a combination of two drugs. The first compound is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]th iophene, and the second compound is tamoxifen.

Treatment of mammary cancer

4-2-(di-n-propylaminoethyl)indole or a salt thereof is used to stimulate presynaptic dopamine autoreceptors in mammals.

Use of 4-(2-di-n-propylaminoethyl)indole or a salt thereof as a

N-[2-(5-methoxy-6-haloindol-3-yl)ethyl]amides are valuable, orally active, ovulation inhibitors.

Amides as ovulation inhibitors

D-2-halo-6-alkyl-8-substituted ergolines and related compounds are inhibitors of prolactin in mammals.

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Indianapolis, IN, United States of America

James A Clemens