University of Texas System

James A Bankson

Jingfei Ma

R Jason Stafford

Haesun Choi

Ananth V Annapragada

Vikas Kundra

Ketan B Ghaghada

Murali K Ravoori

Provided herein are nanoparticle-based gadolinium (Gd) agents which may be used, e.g., in T1-weighted MR imaging (MRI). In various embodiments, dual-Gd liposomal agents are provided which contain both core-encapsulated Gd as well as surface-conjugated Gd. In various embodiments, these agents were observed to deliver a higher concentrations of Gd and result in substantial improvements in signal to noise ratios and contrast to noise ratios. Also provided are methods for in vivo imaging and/or treating diseases such as cancer or tumor in a subject.

Dual mode gadolinium nanoparticle contrast agents

Systems and methods are described for chemical shift magnetic resonance imaging in the presence of multiple chemical species. A method includes obtaining a plurality of MRI data signals using a Dixon technique in combination with partially parallel imaging techniques and/or inversion recovery techniques, and processing the plurality of MRI data signals using a Dixon reconstruction technique to create a chemical specific shift image. An apparatus includes a MRI scanner for obtaining images, a controller configured to provide input to the scanner to acquire images using a Dixon technique in combination with partially parallel imaging techniques and/or inversion recovery techniques to produce a plurality of MRI data signals, and processing the plurality of MRI data signals using a Dixon reconstruction technique to create a chemical specific shift image, and an output device to display the resulting image.

Methods and apparatuses for fast chemical shift magnetic resonance imaging

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Houston, TX, United States of America

James A Bankson