University of Minnesota

Jakub Tolar

Bruce Robert Blazar

Mark J Osborn

Catherine M Verfaillie

Daniel F Voytas

Beau R Webber

Bruce Blazer

Dharmeshkumar Patel

Induced pluripotent stem cells (iPSCs) derived from a T cell of a T cell subset. T cells derived from iPSCs derived from a T cell. Methods of deriving iPSCs from a T cell. Methods of deriving T cells from iPSCs including deriving a T cell of a T cell subset from an iPSC. Methods of engineering chimeric antigen receptor (CAR)-expressing or T cell receptor (TCR)-expressing iPSC. Methods of administering T cells derived using the methods disclosed. Induced pluripotent stem cell lines derived from T cells, methods of deriving induced pluripotent stem cell lines, and methods of deriving T cells from induced pluripotent stem cell lines.

Human T cell derived from T cell-derived induced pluripotent stem cell and methods of making and using

The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

TALEN-based gene correction

Methods of gene correction, methods of generating induced pluripotent stem cells (iPSCs), and methods of deriving multi-lineage cell types with therapeutic value. In some embodiments, the gene correction affects the expression and/or function of the functional type VII collagen protein (C7).

Method for correcting a genetic sequence

Talen-based gene correction

The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells.

Compositions and methods for the treatment of lysosomal storage disorders

Cell therapy for the treatment of lysosomal storage disorders

MAPC administration for the treatment of lysosomal storage disorders

Growing community of inventors

Minneapolis, MN, United States of America

Jakub Tolar