Coloplast A/s

Jakob Vange

Hanne Everland

Petr Sehnal

Brian Nielsen

David Jepson

Andrew Towns

Jens Hassingboe

Peter Boman Samuelsen

Lene Feldskov Nielsen

Peter Sylvest Nielsen

Christian Clausen

Khadija Schwach-Abdellaoui

Monica Ramos Gallego

Lene Karin Jespersen

Coatings for medical devices, e.g. urinary catheters, are provided, which comprise photoinitiator monomers with acrylamide photoinitiator functionality.

Polymeric coatings

Acrylamide photoinitiators are provided, in which a photoinitiator moiety and an acrylamide are incorporated into the photoinitiator structure.

Acrylamide photoinitiators

The present application discloses an alternative method for the formation of non-woven with fibers in the 1 to 200 &#x3bc;m range. Using an aqueous solution of gelatin (optionally with &#x3c;30% of low molecular weight alcohol) the fibers are ejected utilizing pressurized air emitted from nozzle and the non-woven formed directly from the emitted thin fibers. The gelatin non-woven can be cross-linked by heat-treatment or chemical cross-linking, and the non-woven is biocompatible as measured by fibroblast growth in vitro and wound healing on pigs in vivo.

Gelatin non-woven structures produced by a non-toxic dry solvent spinning process

The present invention provides for a composition, for augmentation and regeneration of living tissue in a subject, comprising a population of porous microparticles of a biodegradable polymer, one or more mammalian cell populations, and optionally, a biocompatible adhesive.

Compositions and methods for augmentation and regeneration of living tissue in a subject

The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O&#x2014;(CHRCHRO)&#x2014;B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [&#x2014;CH(CH)&#x2014;COO&#x2014;] and (ii) glycolide units [&#x2014;CH&#x2014;COO&#x2014;] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C-alkyl or hydroxy protecting groups, one of Rand Ris hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [&#x2014;(CHRCHRO)&#x2014;] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

Degradable hydrophilic block copolymers with improved biocompatibility for soft tissue regeneration

A stabilised composition having antibacterial, antiviral and/or antifungal activity, said composition comprising silver ions and a ligand, characterised in that the composition comprises a complex of silver and a ligand selected from the group consisting of 5,5-disubstituted hydantoins in which the substituents do not comprise conjugated unsaturated bonds and barbituric acid and derivatives thereof stabilising silver ions against reduction to free silver in a hydrophilic environment, and that the composition has a solubility in water higher than 10 mg Ag/l is stable during sterilisation and retains the activity without giving rise to darkening or discoloration of the dressing during storage.

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Helsingoer, Denmark

Jakob Vange