Glaxo Group Limited

Glaxosmithkline LLC

Jakob Busch-Petersen

Michael R Palovich

Zehong Wan

Hongxing Yan

Dramane Ibrahim Laine

Chongjie Zhu

Katherine L Widdowson

Christopher E Neipp

Brent W McCleland

Huijie Li

Wei Fu

Jeffrey Charles Boehm

Xichen Lin

Jeffrey K Kerns

Qi Jin

Christopher S Brook

Guoliang Lin

James Brackley, Iii

Yonghui Wang

Anthony W J Cooper

Hongyi Yu

Jianghe Deng

Gregory L Adams

Jack J Taggart

Feng Wang

Kristen E Belmonte

Edward C Webb

Richard M Goodman

This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (Il-8).

IL-8 receptor antagonists

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK&#x3b2;) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Indole carboxamides as IKK2 inhibitors

This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.

Muscarinic acetylcholine receptor antagonists

Novel dimeric benzoazabicyclohepatane compounds, pharmaceutical compositions, processes for their preparation and use thereof in treating Mmuscarinic acetylcholine receptor mediated diseases are disclosed.

[object Object]

Novel thiazole aniline compounds, pharmaceutical compositions, methods of making them and uses thereof in treating Mmuscarinic acetylcholine receptor mediated diseases are disclosed.

Growing community of inventors

King of Prussia, PA, United States of America

Jakob Busch-Petersen