Nanunanu Ltd.

Ortus Medical Limited

The Royal Institution for the Advancement of Learning / Mcgill University

Mcgill University

Jake E Barralet

Uwe Gbureck

Liam M Grover

Benedetto Marelli

Showan Nazhat

Antonio Alessandrino

Roger Thull

Giuliano Freddi

Showan N Nazhat

A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.

Biomaterial of chymotryptically isolated fraction of fibroin in a hydrogel

In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:&#x2014;(i) a powdered component, said powdered component having an average particle size dof less than 15 &#x3bc;m, and (ii) a calcium phosphate based powder, said powder having an average particle size dgreater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:&#x2014;(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least &#x2212;30 mV.

Calcium phosphate bone cements

Fibrous calcium pyrophosphate particles with a unique fibrous nanostructure are disclosed. The invention includes a composition, comprising fibrous particles, wherein the fibrous particles include fibers and the fibers include calcium and pyrophosphate. Also included are methods for making calcium pyrophosphate particles wherein solutions of calcium salt and pyrophosphate salt are combined to form the particles. Pharmaceutical compositions and methods for treating a patent using the disclosed particles are also described.

Fibrous calcium pyrophosphate particles and methods of making and using same

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Montreal, Canada

Jake E Barralet