Postech Foundation

Postech Academy-industry Foundation

Jaiwook Park

Mahn-Joo Kim

Yangsoo Ahn

Jun Ho Choi

Won-Hee Kim

Min Serk Kwon

Kiwon Han

Yoon Kyung Choi

Namdu Kim

Cheon Min Park

The present invention relates to a method of preparing optically active amines and chiral amines prepared thereby. The method includes reacting an amine compound, a metal catalyst, a biocatalyst including a lipase, and an acyl donor compound in an organic solvent to obtain a chiral amide compound, and then hydrolyzing the chiral amide compound to obtain a chiral amine.

Method for preparing optically active amines

A highly active and recyclable supported transition metal catalyst can be prepared by a simple process comprising mixing with heating a transition metal complex, a metal-chelating agent and an alkoxide of Ti, Al or Si, followed by treatment with water to induce a sol-gel reaction among the reactants.

Synthesis of supported transition metal catalysts

A chiral compound, particularly a chiral secondary alcohol, can be efficiently resolved under a mild condition by acylation with an alkenyl acetate in the presence of a novel aminocyclopentadienyl ruthenium complex, an enzyme catalyst, and a base.

Resolution of chiral compounds using aminocyclopentadienyl ruthenium catalysts

Novel aminocyclopentadienyl ruthenium complex is useful as a catalyst in the racemization of a chiral compound.

Aminocyclopentadienyl ruthenium complexes and preparation thereof

Growing community of inventors

Pohang, South Korea

Jaiwook Park