Fundacao De Amparo a Pesquisa Do Estado De Sao Paulo

Jairo Kenupp Bastos

Gustavo Henrique Bianco Souza

Márcio Luis Andrade Silva

Sérgio Albuquerque

Rosângela Silva

The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves ofor. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6, 6'-dinitrohinokinin and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.

Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities

The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves ofor. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6'-dinitrohinokinine and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.

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Ribeirao Preto, Brazil

Jairo Kenupp Bastos