China Medical University

Tairx, Inc.

Jai-Sing Yang

Sheng-Chu Kuo

Li-Chen Chou

Li-Jiau Huang

Tian-Shung Wu

Tzong-Der Way

Kuo-Hsiung Lee

Jing-Gung Chung

Che-Ming Teng

Shiow-Lin Pan

Chung-Ming Sun

Chih-Shiang Chang

Shih-Ming Huang

Ching-Che Huang

Chien-Ting Chen

Jang-Chang Lee

Yang-Chang Wu

Tai-Lin Chen

Mann-Jen Hour

Po-Wu Gean

Hong-Zin Lee

Hui-Yi Lin

Min-Tsang Hsieh

Hsin-Yi Hung

Ling-Chu Chang

Chang-Hai Tsai

Chi-Hung Huang

Mei-Hua Hsu

Chin-Yu Liu

Mei-Chi Fang

Shi-Hong Zhuang

Meng-Tung Tsai

Huei-Wen Chen

Yung-Yi Cheng

Min-tsang Hsieh

Hui-yi Lin

Huei-Wan Chen

A series of novel bis(hydroxymethyl) alkanoate derivatives of curcuminoids were designed, and synthesized, which show anticancer activity, and in particular to breast cancer, colon cancer, and prostate cancer.

Derivatives of curcuminoids and use thereof as an anticancer agent

The present invention provides a series of derivatives of stilbenoid which are useful as new inhibitory agents against head and neck squamous cell carcinoma (HNSCC) and hepatoma.

Stilbenoid compound as inhibitor for squamous carcinoma and hepatoma and uses thereof

Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof:  

2-aryl-4-quinazolinones and their pharmaceutical compositions

2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Naform) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.

2-phenyl-4-quinolones as anticancer agents

2-selenophene-4-quinolones as anticancer agents

2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Naform) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.

Hydrophilic derivatives of 2-selenophene-4-quinolones as anticancer agents

A compound of Formula I is disclosed as follows: 

Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives

2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and &#x39b;/, &#x39b;/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.

Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents

The present invention synthesizes a series of selenolo[3,2-c]pyrazole and selenolo[2,3-c]pyrazole derivatives, and discovers their anticancer activity.

Selenolopyrazole derivatives and use thereof as anticancer agents

Growing community of inventors

Taichung, Taiwan

Jai-Sing Yang