Council of Scientific and Industrial Research

Jai Shanker Arya

Suman Preet Singh Khanuja

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Madan Mohan Gupta

Dharmendra Saikia

Monika Singh

Santosh Kumar Srivastava

Subhash Chandra Gupta

Anirban Pal

Subash Chandra Verma

Ranganathan Santha Kumar Tiruppadiripuliyur

Harpreet Kaur

The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods ofThe present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (&#x2212;) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from moringa oleifera

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Lucknow, India

Jai Shanker Arya