Council of Scientific and Industrial Research

Jai Shankar Arya

Sushil Kumar

Suman Preet Singh Khanuja

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Monika Singh

Soumya Awasthi

Madan Mohan Gupta

Vivek Kumar Gupta

Suresh Haribhau Dawle

Sunil Balkrishna Mansinghka

Prachi Sinha

Subhash Chandra Gupta

Sweta Agarwal

Ram Kishore Verma

Tiruppadiripuliyur Ranganathan Santha Kumar

Krishna Kumar Agarwal

Arun Kumar Tripathy

Sarita Satapathy

Subhash Chandra Singh

Laiq Ur Rahman

Atique Ahmad

Subhas Chandra Gupta

Puspalata Chatruvedi

The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

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The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside 'glycyrrhizin' as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

Use of bioactive fraction from cow urine distillate ('go-mutra') as a bio-enhancer of anti-infective, anti-cancer agents and nutrients

The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of antifungal compounds. The plant compounds, menthol and menthyl acetate, when mixed at specific concentrations, enhance the antifungal activity of the commercially available fungicides.

Method of treatment for fungal infections with a synergistic formulation of antifungal agents

The present invention provides a novel synergistic composition comprising extract obtained from the plant together with &dgr;-endotoxin, useful in controlling lepidopteran insects, methods for the preparation of the composition and application of the insecticidal composition to standing crops.

Process of its application against lepidopteran insects using Albizzia lebbeck plant extract and Bacilus thuriengiensis delta-endotoxin

A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

Pharmaceutical composition containing cow urine distillate and an antibiotic

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Lucknow, India

Jai Shankar Arya