Zumutor Biologics Inc.

Jahnabi Arika

Sanghamitra Bhattacharjee

Vivek Halan

Maloy Ghosh

Kavitha Iyer Rodrigues

Sunit Maity

Bharath Ravindra Shenoy

Sohang Chatterjee

Divya Unnikrishnan

Bhargav Prasad

Anuradha Hora

Karthika Nair

Sankaranarayanan Srinivasan

Aswini Thanigaivel

Amol Maliwalave

Pravin Kumar D

Sathyabalan M

Veeresha K

Yogendra Manjunath B M

Bairavabalakumar N

Rajeshwari Pendse

Prabhat Kumar Pathak

Anisha Kurup

Pavithra M

The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.

Non-fucosylated protein and methods thereof

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Bengaluru, India

Jahnabi Arika