Hznp Limited

Nuvo Research Inc.

Nuvo Pharmaceuticals Inc.

Crescita Therapeutics Inc.

Jagat Singh

John Michael Newsam

Edward Thomas Kisak

Bradley S Galer

Ed Kisak

Robert Dominic King-Smith

Lisa Marie Grierson

Maria Burian

Jonathan Wilkin

Joseph Zev Shainhouse

Servet Buyuktimkin

Nadir Buyuktimkin

Dominic King-Smith

The present invention provides DMSO-containing foamable formulations, methods for preparation, and methods of treatment. The formulations can provide good permeability and bioavailability at the target site. Preferably, the formulations are useful for treating osteoarthritis. In one embodiment, the invention provides a foamable formulation for topical use, said formulation comprising DMSO, polyalkylene glycol alkyl ether, an active agent, a monohydric lower alcohol, a diol, and water. Preferably, the active agent is a non-steroidal anti-inflammatory drug, such as diclofenac sodium or ibuprofen.

Foamable formulation

The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.

Treatment of pain with topical diclofenac

The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.

Diclofenac topical formulation

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Toronto, Canada

Jagat Singh