Centre National De La Recherche Scientifique

Universitéde Strasbourg

Etat Francais (ministère Des Armées), Represente Par La Direction Centrale Du Service De Santé Des Armees

Jagadeesh Yerri

Rachid Baati

José Dias

Richard Brown

Alex Maryan-instone

The present invention relates to a compound of formula (I), or one of its pharmaceutically acceptable salts: (I) wherein R1, R2 and —X—Y— have specific definitions. It also relates to the use of such a compound in therapy; and to a process for preparing it.

3,6-disubstituted-2-pyridinaldoxime scaffolds

Disclosed is a compound of formula (II), as well as to a process for preparing the compounds of formula (II) by a chemoselective Sonogashira reaction. It also relates to a pharmaceutical composition including at least one compound of formula (II) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer; and/or for use as antiviral drug.

6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds

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Strasbourg, France

Jagadeesh Yerri