Codexis, Inc.

Jagadeesh Mavinahalli

Steven James Collier

Yong Koy Bong

Oscar Alvizo

Emily Mundorff

Derek J Smith

Wan Lin Yeo

Behnaz Behrouzian

Shiwei Song

Anupam Gohel

Naga K Modukuru

Michael A Crowe

Vesna Mitchell

Michael Vogel

Xiyun Zhang

Jack S Liang

John M Gruber

Benjamin Mijts

Lisa Marie Newman

Michael D Clay

James Joseph LaLonde

Roger Arthur Sheldon

Sheela Muley

John D Munger, Jr

Jeffrey Colbeck

Jun Zhu

Jian Ding

The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Biocatalysts for ezetimibe synthesis

Biocatalysts for Ezetimibe synthesis

The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of &#x3b1;-chloroalcohols from &#x3b1;-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.

Ketoreductase-mediated stereoselective route to alpha chloroalcohols

The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of &#x3b1; chloroalcohols from &#x3b1; chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.

Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein.

Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

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Maharashtra, India

Jagadeesh Mavinahalli