Sk Chemicals Co., Ltd.

Tiumbio Co., Ltd.

Jaeseung Ahn

Hyun Jung Lee

Jae-Sun Kim

Ju Young Lee

Bong-Yong Lee

Hun-Taek Kim

Je Ho Ryu

Min-Young Han

Taekyung Yoo

Euisun Park

So-young Lee

Hyun-Jung Lee

Dong Chul Shin

Jung A Lee

Seon-Mi Kim

Keun-Ho Ryu

Young-Ah Shin

Sang-hwan Kang

Minhee Lee

Joon Ho Sa

Dong-Chul Shin

Yong-Hyuk Kim

Jeong A Lee

Young Ah Shin

Jeongmin Seo

Hoechul Jung

So-Young Lee

Sang-Hwan Kang

The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-&#x3b2; (TGF-&#x3b2;) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.

2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

The present invention relates to: a compound selected from the group consisting of a tricyclic compound having the structure of formula I, a pharmaceutically acceptable salt, an isomer, a solvate and a precursor thereof; and a use thereof. The compound effectively controls GPR40, and thus, can be effectively used for the prophylaxis or treatment of diseases associated with GPR40, for example, diabetes and many other diseases.

Tricyclic compound and use thereof

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.

Gonadotropin releasing hormone receptor antagonists, method for the preparation thereof and pharmaceutical composition comprising the same

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Seoul, South Korea

Jaeseung Ahn