Chong Kun Dang Pharmaceutical Corporation

Lg Electronics Inc.

JaeKwang Lee

NiNa Ha

Hyeseung Song

Jung Taek Oh

Taesoo Park

Daekwon Bae

ChangSik Lee

Hongrae Cha

JaeWon Lee

Suyeal Bae

SeoHee Lee

Sera Lee

Hyang Kim, Ii

The present invention relates to novel heterocyclicalkyl derivatives having histone deacetylase (HDAC) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel heterocyclicalkyl derivatives. The novel heterocyclicalkyl derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be effectively used for the treatment of histone deacetylase-mediated diseases, such as cell proliferative diseases, inflammatory diseases, autosomal dominant diseases, genetic metabolic diseases, autoimmune diseases, acute/chronic neurological disease, hypertrophy, heart failure, ocular diseases, or neurodegenerative diseases.

Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same

The present invention relates to cycloalkenyl aryl derivatives, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof, or solvates thereof; a method for preparing the derivatives; and pharmaceutical compositions containing the same. The compounds of the present invention show the effect of CETP activity inhibition. It means that the compounds can increase HDL-cholesterol and decrease LDL-cholesterol.

Cycloalkenyl aryl derivatives for CETP inhibitor

An apparatus and a method of displaying 3-Dimensional image are disclosed. A camera unit serves to capture an image of a viewer. A position tracking device serves to detect a position of the viewer using a video frame included in the captured image and calculate a position of a non-transmissive region of a 3D image filter based on the detected position of the viewer. A display unit serves to move the non-transmissive region of the 3D image filter according to the calculated position of the non-transmissive region. Changing a sweet spot of the 3D image to suit movement of the viewer has the effects of enlarge a viewing angle of the viewer and preventing crosstalk and image flipping even when the viewer moves.

Apparatus and method of displaying 3-dimensional image

Growing community of inventors

Yongin-si, South Korea

JaeKwang Lee