Aprecia Pharmaceuticals LLC

Massachusetts Institute of Technology

Therics, Inc.

Aprecia Pharmaceuticals Company

Other

Jaedeok Yoo

Thomas George West

Thomas J Bradbury

Henry Leon Surprenant

James Iskra

Thomas J Bebb

Donald C Monkhouse

Chen-Chao Wang

Michael John Cima

Sandeep Kumar

Jill K Sherwood

Esteban Bornancini

Christopher M Gaylo

Aleece M Phillips

Qing Wen Liu

Francis C Payumo

Willie J Roach

Sunil Saini

Peter A Materna

Mahendra R Patel

Charles William Rowe

Timothy J Pryor

Kelly E Caputo

Alfred Anthony Litwak

Monica Tejwani

Kathleen D Chesmel

Jonathan McGlohorn

Mahesh Krishnan

Heather Ann Beam

Timothy S Tracy

Jennifer Patterson

Munhee Lee

William R Gross

Henry Cabral

Matthew F Boldt

Monica Rewachand Motwani

Lauren E Beach-Herrera

Henry L Surprenant

A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside.

Rapidly-orodispersible tablets having an interior cavity

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Three-dimensional printing system and equipment assembly

Rapidly-orodispersible tablets having an in interior cavity

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.

Method and system for forming a dosage form within a packaging

A rapidly dispersing dosage form is described. The dosage form releases its active ingredients within a period of less than about ninety seconds. These dosage forms exhibit a three-dimensional shape that is retained for adequate storage but is readily dispersed in the presence of excess moisture. Also disclosed are methods of administration of a medicament and a process for the preparation of rapidly dispersing dosage forms.

Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same

A rapidly dispersing dosage form is described, which releases its active ingredients within a period of less than about ninety seconds. These dosage forms exhibit a three-dimensional shape that is retained for adequate storage but is readily dispersed in the presence of excess moisture. Also disclosed are methods of administration of a medicament and a process for the preparation of rapidly dispersing dosage forms.

The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.

Diffusion-controlled dosage form and method of fabrication including three dimensional printing

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Princeton, NJ, United States of America

Jaedeok Yoo