Korea Kumho Petrochemical Co., Ltd.

Korea Research Institute of Bioscience and Biotechnology

Institute for Research & Industry Cooperation, Pnu

Jae Yun Kim

Yeong Min Jung

Young Hoon Ko

Eun Kyung Noh

Jin Man Hwang

Min Sung Kwon

Hoo Chae Kim

Ki Hyun Kim

Tae Hee Kim

Yee Sook Cho

Gwang Hoon Kwag

Dong Eun Kang

Sang Chul Ji

Sun Woo Cheen

Binna Seol

Hyun Jong Paik

Won Ho Kim

Han-Seop Kim

Han Baek Lee

Soojung Park

Eun Kyung No

Jong Yeop Lee

Hee Jeong Kim

Ok Kil Mun

Seon Kyeong Cheong

Soo Jung Park

Mycong Seup So

The present invention relates to: a method for producing immunocytes, specifically induced natural killer T (iNKT) cells that are induced by direct reprogramming of isolated somatic cells, and chimeric antigen receptor (CAR)-iNKT cells into which a CAR gene encoding a CAR is introduced; iNKT cells produced by the method; and a cell therapy composition and a pharmaceutical composition for preventing or treating cancer, comprising the iNKT cells. The method according to the present invention can produce, through direct reprogramming, iNKT cells or iNKT cells into which a CAR gene is introduced, from isolated cells so as to simplify the production process and shorten production time, thereby reducing costs, to have excellent NKT cell production efficiency, and to ensure safety according to the production without passing through induced pluripotent stem cells, thereby having an excellent NKT cell production effect distinguished from that of a conventional reprogramming technique. In addition, the iNKT cells or iNKT cells into which a CAR gene is introduced, which are produced by the method, have an excellent cancer cell killing ability, and thus can be effectively used as a cell therapy composition or a pharmaceutical composition for preventing or treating cancer.

Method for producing immune cells and use thereof

Proposed is a rubber composition for a tire tread, which includes: a solution-polymerized elastomer having a conjugated diene-based monomer unit, a solution-polymerized elastomer having an aromatic vinyl monomer unit and a conjugated diene-based monomer unit, or a combination thereof, at 100 parts by weight; and a plasticizer containing an aromatic petroleum resin and an aliphatic olefin polymer, at 10 to 50 parts by weight. Further, a manufacturing method of the rubber composition for a tire tread is proposed.

Rubber composition for tire tread and manufacturing method thereof

A method of manufacturing a rubber composition is provided. The method includes: (a) allowing a mixture including a conjugated diene-based monomer to react in the presence of a first catalyst; (b) introducing a carboxylic acid-based compound into the product of the step (a) to deactivate the first catalyst; and (c) introducing a second catalyst and a conjugated diene-based monomer into the product of the step (b) and allowing the second catalyst and the conjugated diene-based monomer to react with the product of the step (b).

Method of manufacturing rubber composition

According to an embodiment of the present invention, there is provided a method of preparing a rubber composition, which includes (a) synthesizing a living polymer by solution polymerization of a monomer mixture including a conjugated diene-based monomer in the presence of a first catalyst; (b) reacting some ends of the living polymer with a coupling agent; (c) reacting the remaining ends of the living polymer with an organotin halide compound to prepare an end-modified conjugated diene-based polymer solution; and (d) adding a second catalyst and a conjugated diene-based monomer to the end-modified conjugated diene-based polymer solution to induce solution polymerization.

Method of preparing rubber composition including syndiotactic 1,2-polybutadiene

Provided is a method of preparing a rubber composition, which includes (a) reacting a conjugated diene-based monomer with one or more of compounds in the presence of a first catalyst; (b) adding a conjugated diene-based monomer to a product of the step (a) and inducing a reaction; and (c) adding a second catalyst and a conjugated diene-based monomer to a product of the step (b) and inducing a reaction.

One aspect of the present invention provides an additive composition for polymer-modified asphalt including a block copolymer having a radial structure and a copolymer of an aromatic vinyl compound of which two ends have different molecular weights and a conjugated diene compound, and a method of preparing the same. When asphalt is prepared using the additive composition for polymer-modified asphalt, properties of the existing polymer-modified asphalt may be maintained while content of sulfur may be reduced, viscosity may decrease, and thereby processability and pavement performance may be improved.

Additive composition for polymer-modified asphalt, polymer-modified asphalt composition comprising the same, and method for preparing the same

Disclosed is an interfacial polymer for a network used as a coupling agent in mixing of rubber-silica. More particularly, the interfacial polymer for a rubber-silica network is a block copolymer containing a copolymer of conjugated diene and vinyl aromatic monomers, in which when used as a coupling agent in the mixing of synthetic rubber and silica (an inorganic material), the polymer enhances silica dispersibility within the rubber, and improves compatibility and processability, resulting in considerable improvement in the dynamic property as well as the mechanical property of the rubber, and when used in a tire, etc., it enhances automobile braking performance and reduces rolling resistance.

Interfacial polymer for rubber-silica network

Provided is a tapered block copolymer having asymmetric vinyl aromatic blocks. The disclosed tapered block copolymer has very superior adhesion properties such as loop tack, 180&#xb0; peel strength and softening point and may be used to prepare high-quality hot melt adhesives for industrial use.

Tapered asymmetric block copolymers and adhesives composition comprising the same

Disclosed is a modified asphalt composition including a styrenic block copolymer and a vegetable wax as modifier. With lower viscosity at high temperatures as compared to the asphalt composition modified only with the styrenic block copolymer, it can be manufactured and used at lower temperatures. Also, with higher ductility at low temperatures, it can minimize fatigue crack even in cold weathers.

Asphalt compositions modified by styrenic block copolymer and vegetable wax

The present invention relates to an adhesive composition comprising a mixture of multi-block copolymers, in particular, an adhesive composition comprising a block copolymer represented by Formula 1, a hydrocarbon adhesive resin and a plasticizer. The adhesive composition according to the present invention can be easily processed due to its low melting point and shows improved adhesive properties such as loop tack, 180&#xb0; peel strength and holding power.

Adhesives composition comprising mixtures of multi-block copolymers

This invention relates to a process for selectively hydrogenating the unsaturated double bonds of conjugated diene units of a homopolymer or copolymer. By using a highly active novel homogeneous organo titanium catalyst represented by formula (I) and lithium hydride (LiH) prepared in solution of organo lithium compound and hydrogen as a reducing agent, a polymer could be hydrogenated with significantly high yield and good reproducibility. In addition, this invention is characterized by a novel method in that when a copolymer containing a conjugated diene and vinyl-substituted aromatic hydrocarbon, the unsatured double bonds of conjugated diene units are selectively hydrogenated. In said formula where, Cp is a cyclopentadienyl group (CH); Rand Rare the same or different and are selected from halogen atom; Rand Rare the same of different and are selected from hydrogen atoms, alkyl or alkoxy group containing 1 to 12 carbon atoms, aryl or aryloxy groups containing 6 to 20 carbon atoms and cycloalkyl groups containing 6 to 20 carbon atoms.

Process for hydrogenating a conjugated diene polymer

Method for the selective hydrogenation of polymer containing conjugated diene

This invention is to provide a process for the hydrogenation of conjugated diene polymer in an inert organic solvent, said polymer being obtained by polymerization or copolymerization of a conjugated diene, which comprise effecting selective hydrogenation of unsaturated double bonds in the conjugated diene units of said conjugated diene polymer in the presence of catalyst represented by the following formula (I) ##STR1## wherein Cp is cyclopentadienyl (C.sub.5 H.sub. --);

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Daejeon, South Korea

Jae Yun Kim